More than 5,000 years of heavy agricultural labour by women can be read from the bones found in ancient cemeteries from the Neolithic to Iron Age times. Cambridge University anthropologist Alison Macintosh compared the arm bone dimensions and strength of women from these times with those of modern female athletes such as runners to rowers. Her conclusion is that average upper body strength of women through the Neolithic to the Iron age times exceeded that of today's semi-elite female rowers.A laboratory at the Scripps Research Institute have created a semi-synthetic bacterium with two new man-made genetic letters in its DNA, in addition to the natural four A, G, T and C. What's more, the engineered microbe can use its enhanced genetic alphabet to build synthetic amino acids into the proteins it makes. Chemist Floyd Romesberg talks to Adam Rutherford about what we can learn from his team's extraordinary feat of synthetic biotechnology, what we might gain from it and why, in his opinion, we've no need to be worried.Adam deals with some of your correspondence on axolotls by talking to laboratory salamander breeder Randal Voss at the University of Kentucky. He also notes listeners' comparisons of the recent visit by interstellar asteroid Oumuamua with the alien vessel in Arthur C Clarke's 'Rendezvous with Rama'.Cosmologist and AI researcher Max Tegmark visits BBC Inside Science to discuss the possibility of artificial intelligence machines with super-intelligence and how humanity should be preparing for their advent.Producer: Andrew Luck-Baker.
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A weekly programme that illuminates the mysteries and challenges the controversies behind the science that's changing our world.
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Folge vom 30.11.2017Prehistoric Strong Women, Semi-synthetic Life, Listener Feedback, Artificial Superintelligence
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Folge vom 23.11.2017Interstellar visitor, Svante Paabo, Synthetic biology, Plight of the AxolotlOn 19th October, a mysterious object sped through our solar system. It was first spotted by astronomers with a telescope in Hawaii. Its trajectory and speed told of its interstellar origins. It is the first body to be detected from outside our solar system. Scientists are now publishing their papers on the enigmatic visitor. They estimate that it was about 400 metres long and bizarrely elongated in shape. Adam Rutherford talks to astronomer Alan Fitzsimmons of Queens University in Belfast. Twenty years ago, geneticist Svante Paabo began a revolution in human evolution science when he extracted fragments of DNA from the 40,000 year old bone of a Neanderthal. Among other first, he went onto sequence the entire genome sequence of Homo Neanderthalenisis. Professor Paabo was in the UK this week at a conference on DNA and human evolution at the Wellcome Genome Campus to mark the anniversary. He tells Adam about one of the new directions of research for him now.What does the future hold for synthetic biology? Who will be the practitioners of this fast-growing branch of bioengineering and what will be its impact on the world - for good and possibly ill? Experts in the field have just published a horizon-scanning report in the journal eLife. One of its authors, Jenny Molloy of the University of Cambridge, talks to Adam about the nascent democratisation of the discipline and where this might lead the field and society.The paradoxical plight of the axolotl: popular aquarium pet, laboratory animal and critically endangered species in the wild. This species of salamander is a wonder of nature. It's the amphibian that never grows out of its larval stage yet it's able to reproduce. Most remarkable is its ability to regrow limbs, which is of great potential interest to researchers developing regenerative medicine. There are many thousands of axolotls in labs and homes around the world. But in the wild, in their native Mexico, they are on the very edge of extinction. Inside Science talks to conservation biologist Richard Griffiths of the University of Kent and axolotl researcher Tatiana Sandoval Guzman of the Technical University in Dresden, Germany.Producer: Andrew Luck-Baker.
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Folge vom 16.11.2017Can we forecast earthquakes?, Britain's space race rocket Skylark, Francis GaltonWhat might the length of the day have to do with the likelihood of destructive earthquakes around the world? According to Professors Rebecca Bendick and Roger Bilham, there's a correlation between changes in the rate at which the Earth rotates and the incidence of earthquakes of Magnitude 7 and above. The rotation speed of the planet increases and decreases over periods of years and decades. From their research, the earth scientists say that there's an substantial increase in the number of powerful earthquakes around the world five years after the Earth attains a peak in its spin speed and enters a period of slow down. The difference in day length is tiny but it is enough, say the researchers, to trigger already stressed faults in the crust to move sooner than later.In the year that the Soviet Union launched Sputnik into orbit, the UK launched its own rocket into the Space Race. 1957 saw the launch of the first Skylark space rocket. Inside Science talks to two veterans of the Skylark programme - Professors John Zarnecki and Ken Pounds - who cut their space research teeth with some of the 440 launches. The Science Museum in London is staging a Skylark exhibition in celebration.Francis Galton was one of the UK's most influential 19th century scientists and laid important methodological foundations for genetics and other fields of science today. But he was also a racist and leading proponent of eugenics. Adam discusses Galton's legacy with historian Subhadra Das of University College London and clinical geneticist Han Brunner of the Maastricht University Medical Centre in the Netherlands. Both guests attended a meeting of the Galton Institute in London which brought together researchers of many disciplines to discuss the bad and the good in Francis Galton's legacy.Producer: Andrew Luck-Baker.
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Folge vom 09.11.2017Boy gets New Skin, The York Gospels, Stephen Hawking's ThesisResearchers in Italy and Germany have saved the life of a boy with a life threatening genetic skin disease, using a combination of stem cell and gene therapy. 7 year old Hassan had lost 60% of his protective epidermis because of the condition, junctional epidermolysis bullosa. The severe blistering and consequent bacterial infections put his life in imminent danger. In a final attempt to save him, the scientists took a small area of unblistered epidermis from his body, separated the constituent skin cells and then engineered them with a normal version of the gene that was malfunctioning in Hassan's body. Sheets of healthy epidermis of an area of about one square metre were then grown in culture, and then grafted onto 80% of his body. Hassan is now living a normal life, back at school, playing football. Lead researcher Michele de Luca describes the remarkable recovery and Fiona Watt, director of the Centre for Stem Cell and Regenerative Medicine at Kings College London, explains how the procedure worked.Scientists at the University of York are investigating medieval livestock farming through the study of the 1,000 year old York Gospels manuscript: not by reading it but by extracting proteins and DNA from its animal skin parchment pages. Inside Science listener and Middle Eastern archaeologist Melissa Sharp takes the programme to task for suggesting that anyone can now use publically available sonar and satellite data to search for shipwrecks and other archaeological sites. It opens up the world's ancient and not so ancient heritage to looters, she says. Since the University of Cambridge made Stephen Hawkings 1966 PhD thesis free to view and download last month, more than a million people have at least looked at it. Adam Rutherford talks to cosmologist Andrew Pontzen, biologist Matthew Cobb and neuroscientist Sophie Scott about the record-breaking thesis and asks whose first research project they'd like to download.Producer: Andrew Luck-Baker