We now know that Neanderthals and our ancestors interbred over 40,000 years ago. Recent research has shown that most people of European or East Asian descent carry a small percentage of Neanderthal DNA - about 2%. But two new papers this week examine some of the physical characteristics we may have got from the genes of our ancient cousins. They include some disease susceptibilities and hair and skin characteristics, which may have helped our forebears survive in northern climes.There have been many sensationalist headlines in the news this week suggesting that the deadly bubonic plague could return, when really, it never went away. And while it can still be deadly, it can be treated early with antibiotics. In the Middle Ages the Black Death is thought to have killed up to half of the European population and so too did the Justinian Plague 800 years earlier. Now scientists have compared these two plague genomes to find that they were both caused by distinct strains of the same bacterium, Yersinia Pestis. Knowing how the pathogen evolved in the past is crucial to our understanding of possible future strains of plague. Lead author Dr David Wagner from the University of Arizona tells Dr Adam Rutherford that it's very unlikely the plague will return on a mass scale.It's a windy Show Us Your Instrument this week - Prof Konstantinos ('Kostas') Kontis, Professor of Aerospace Engineering shows us around his wind tunnel. It's used to help develop more effective plane wings, helicopter rotors, and wind turbine blades, but cyclist Sir Chris Hoy has also been a test sample. Glasgow University is currently building a hypersonic wind tunnel, which can test air flow at speeds of up to Mach 10.We all unconsciously synchronise our movements and researchers at the University of Birmingham have shown how professional musicians make tiny adjustments in their playing to keep time with their colleagues. Alan Wing, Professor of Human Movement in Psychology tells Adam how this research about minute synchronisation is helping to inform how robots can be designed to interact with humans.Stem cells can become any other cell in the body from nerve to bone to skin, and they are touted as the future of medicine. Embryos are one, often ethically charged, source of stem cells and in 2006 Nobel prize winning research showed that skin cells could be "genetically reprogrammed" to become stem cells. These were called induced pluripotent stem cells. Scientists in Japan have now shown, in mice, that this previous painstaking method of making the versatile cells can be replaced by little more than a short dip in acid. Professor Chris Mason from University College London tells Adam that this major breakthrough could be faster, cheaper and possibly safer than other cell reprogramming technologies.Producer: Fiona Hill.
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Folge vom 30.01.2014Neanderthals; Plague; Wind Tunnel; Music Timing; Stem Cells
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Folge vom 23.01.2014Higgs Boson; Neutrinos; Antarctic echo locator; Rainforest fungi; Alabama rotThe Higgs boson has been discovered, providing the final piece of the jigsaw puzzle for the Standard Model of particle physics, a description of how the universe works. But what physicists haven't found yet, which they should have, are supersymmetry or SUSY particles. Roland Pease attended a recent meeting of top physicists, and shares with Adam Rutherford the latest discussions about where to look next.The history of neutrinos is littered with interesting characters. It was Wolfgang Pauli who first suggested their existence. Pauli was so unsettled by his proposal that he bet a case of champagne against anyone being able to discover these "pathologically shy" particles. Since then, scientists have built ever more elaborate experiments to try and detect these particles. Ray Jayawardhana, Professor of Astrophysics and author of a new book "The Neutrino Hunters" explains more about the most abundant particle in the universe.This week's Show Us Your Instrument is a tool used to help scientists measure the glaciers in the Antarctic. Julian Dowdeswell, a glaciologist from the University of Cambridge, uses an echo-locator to look at the dynamics of large ice masses and their response to climate change.Fungi, not viewed favourably by gardeners, can be good for rainforest biodiversity. Dr Owen Lewis from Oxford University tells Melissa Hogenboom that plots sprayed with fungicide soon become dominated by a few species at the expense of many others, leading to a marked drop in diversity.A mysterious illness killing dogs has been in the headlines this week. David Walker a veterinary specialist, says that although it's not clear what's causing the disease, people should not panic.
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Folge vom 16.01.2014Personal genetics kits; Persister cells; Earthquake mapping; ScorpionsFor a couple of hundred quid, one of many companies will send you a kit for sampling your own genome, and most will tell you your genetic risk for some diseases. In December the US Food and Drug Administration imposed a ban on one of these companies, 23andme. The reasoning was that if the organisation is offering medical advice, it needs to be medically regulated. Geneticist Professor Robert Green from Harvard Medical School argues that people can cope responsibly with their genetic information and that the FDA is being over-cautious.Most people are familiar with recurrent infections caused by bacteria such as tonsillitis and bladder infections, where you pick up an infection, get treated with antibiotics and then after a few weeks or months the infection reappears and you need another course of antibiotics; this is a problem that can go on for many years, and is a major healthcare burden world-wide. Marnie Chesterton met a team from Imperial College studying the elusive persister cells responsible for these relapses.Earthquakes usually occur in subduction zones, where one tectonic plate plunges beneath another. Now a team at University of Aberdeen has analysed a large earthquake database and developed a global map giving clues to which areas could be capable of causing giant earthquakes. Professor Nicholas Rawlinson explains the difficulties of predicting.The venom of scorpions contains neurotoxins, which attack the nervous system of animals - it's one of the reasons why it's not a good idea to be stung by a scorpion. The structure of these toxins very closely resembles the structure of a group of proteins with a completely different purpose, called defensins. Professor Jan Tytgat from KU Leauven suggests that venom evolved from these defensins.
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Folge vom 09.01.2014Antarctica weather and climate change; GM Fish Oils; Melanin Fossils; Time TravelScientists following in the footsteps of Edwardian explorer, Douglas Mawson, have been trapped in pack ice in the Antarctic. The Chinese vessel that came to their rescue also became "beset" in the ice. The BBC's Andrew Luck Baker talks to Adam Rutherford about the catacylsmic event that caused multi-year ice to break away and trap the Academik Shokalskiy and Professor John Turner of the British Antarctic Survey underlines the importance of differentiating between extreme weather events and the impact of climate change.A team at Rothamsted Research in Hertfordshire has succeeded in genetically engineering plant seeds to contain the Omega-3 oil usually found in oily fish. Seeds from Camelina sativa (false flax) plants were modified using genes from microalgae - the primary organisms that produce these beneficial fatty acids.The oil has now been incorporated into salmon feed to assess whether it's a viable alternative to wild fish oil. Dr Johnathan Napier tells Melissa Hogenboom that he hopes the plants will provide a sustainable source of long chain polyunsaturated fatty acids.From fossils we know an awful lot about the animals that walked on the Earth, swam in the sea and flew in the air. But fossils have never been good at revealing the colour of these animals. With increasingly sophisticated sampling techniques however, scientists are starting to get a much better, technicolour glimpse into these extinct fauna. And it turns out that colour played a much more important role than just camouflage and decoration. Johan Lindgren form Lund University in Sweden has been finding out how the pigment, melanin, allowed ancient marine reptiles to travel all over the oceanic globe.Show Us Your Instrument: Dr Andrew Polaszek, Head of Terrestrial Invertebrates at the Natural History Museum reveals his compound microscope (with Nomarski Differential Interference Contrast) which he uses to discover "hidden biodiversity", particularly in parasitoid wasps.Stephen Hawking threw a party for time travellers and issued the invitation after the event. Astrophysicists after a long poker game decided to use Twitter instead, to flush out the time travellers in our midst. Professor Robert Nemiroff from Michigan Tech University and his students mined social media for references to the Comet ISON and the naming of the new Pope Francis, before both those events had actually happened. Producer: Fiona Hill.