In Our Time Folgen

Melvyn Bragg and guests discuss the properties of atoms or molecules with a single unpaired electron, which tend to be more reactive, keen to seize an electron to make it a pair. In the atmosphere, they are linked to reactions such as rusting. Free radicals came to prominence in the 1950s with the discovery that radiation poisoning operates through free radicals, as it splits water molecules and produces a very reactive hydroxyl radical which damages DNA and other molecules in the cell. There is also an argument that free radicals are a byproduct of normal respiration and over time they cause an accumulation of damage that is effectively the process of ageing. For all their negative associations, free radicals play an important role in signalling and are also linked with driving cell division, both cancer and normal cell division, even if they tend to become damaging when there are too many of them.With Nick Lane Professor of Evolutionary Biochemistry at University College LondonAnna Croft Associate Professor at the Department of Chemical and Environmental Engineering at the University of NottinghamAnd Mike Murphy Professor of Mitochondrial Redox Biology at Cambridge UniversityProducer: Simon Tillotson

Melvyn Bragg and guests discuss Bernard Mandeville (1670-1733) and his critique of the economy as he found it in London, where private vices were condemned without acknowledging their public benefit. In his poem The Grumbling Hive (1705), he presented an allegory in which the economy collapsed once knavish bees turned honest. When republished with a commentary, The Fable of the Bees was seen as a scandalous attack on Christian values and Mandeville was recommended for prosecution for his tendency to corrupt all morals. He kept writing, and his ideas went on to influence David Hume and Adam Smith, as well as Keynes and Hayek.With David Wootton Anniversary Professor of History at the University of YorkHelen Paul Lecturer in Economics and Economic History at the University of SouthamptonAnd John Callanan Senior Lecturer in Philosophy at King’s College LondonProducer: Simon Tillotson

In the second of two programmes marking In Our Time's 20th anniversary on 15th October, Melvyn Bragg and guests discuss Shakespeare's versions of history, continuing with the Roman plays. Rome was the setting for Titus Andronicus, Julius Caesar, Coriolanus and parts of Antony and Cleopatra and these plays gave Shakespeare the chance to explore ideas too controversial for English histories. How was Shakespeare reimagining Roman history, and what impact has that had on how we see Rome today? The image above is of Marlon Brando playing Mark Antony in a scene from the film version of Shakespeare's Julius Caesar, 1953WithSir Jonathan Bate Provost of Worcester College, University of OxfordCatherine Steel Professor of Classics and Dean of Research in the College of Arts at the University of GlasgowAnd Patrick Gray Associate Professor of English Studies at Durham UniversityProducer: Simon Tillotson