Radiolab Folgen

Today, we return to the lab of neuroscientist Li-Huei Tsai, which brought us one of our favorite stories from four years ago - about the power of flashing lights on an Alzheimer’s-addled (mouse) brain. In this update, Li-Huei tells us about her team’s latest research, which now includes flashing sound, and ways in which light and sound together might retrieve lost memories. This new science is not a cure, and is far from a treatment, but it’s a finding so … simple, you won’t be able to shake it. Come join us for a lab visit, where we’ll meet some mice, stare at some light, and come face-to-face with the mystery of memory. We can promise you: by the end, you’ll never think the same way about Christmas lights again. Or jingle bells. This update was reported by Molly Webster, and produced by Rachael Cusick. The original episode was produced by Annie McEwen, Matt Kielty, and Molly Webster, with help from Simon Adler.  Special thanks to Ed Boyden, Cognito Therapeutics, Brad Dickerson, Karen Duff, Zaven Khachaturian, Michael Lutz, Kevin M. Spencer, and Peter Uhlhaas. Support Radiolab by becoming a member today at Radiolab.org/donate.     Molly's note about the image: Those neon green things in the image are microglia, the brain’s immune cells, or, as we describe them in our episode, the janitor cells of the brain. Straight from MIT’s research files, this image shows microglia who have gotten light stimulation therapy (one can only hope in the flicker room). You can see their many, super-long tentacles, which would be used to feel out anything that didn’t belong in the brain. And then they’d eat it! Further reading:  Li-Huei and co’s gamma sound and light paper: Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition  

Six years ago, a new infection began popping up in four different hospitals on three different continents, all around the same time. It wasn’t a bacteria, or a virus. It was ... a killer fungus. No one knew where it came from, or why. Today, the story of an ancient showdown between fungus and mammals that started when dinosaurs disappeared from the earth. Back then, the battle swung in our favor (spoiler alert!) and we’ve been hanging onto that win ever since. But one scientist suggests that the rise of this new infectious fungus indicates our edge is slipping, degree by increasing degree. This episode was reported by Molly Webster, and produced by Molly and Bethel Habte, with production help from Tad Davis. Special thanks to Julie Parsonnet and Aviv Bergman.  If you caught this segment in our radio broadcast and want to hear the segment it aired with, check out Covid Crystal Ball here. Support Radiolab today at Radiolab.org/donate.   Further Fungus Reading: NYTimes feature on the mysterious rise of Candida auris.   Arturo's paper: “On the emergence of Candida auris, Climate Change, Azoles, Swamps, and Birds”, by Arturo Casadevall, et al. “On the Origins of a Species: What Might Explain the Rise of Candida auris?”, a report from the CDC.  

How close can words get you to the truth and feel and force of life? That's the question poking at our ribs this hour, as we wonder how it is that the right words can have the wrong meanings, and why sometimes the best translations lead us to an understanding that's way deeper than language. This episode, a bunch of stories that play out in the middle space between one reality and another — where poetry, insult comedy, 911 calls, and even our own bodies work to close the gap. Support Radiolab today at Radiolab.org/donate.   Special thanks for the music of Brian Carpenter's Ghost Train Orchestra